Köllner’s Law

Köllner’s Law describes a correlation between the affected Opponent Channel (red-green or blue-yellow) in degenerative, Acquired CVD and the origin of the eye disease causing the CVD:

• Diseases of the outer retina (namely the Photoreceptors) and media changes (e.g. lens yellowing) will tend to result primarily in blue-yellow color defects. This is likely because S-Cones are more susceptible to ischemia and oxidative damage, and their loss is more noticeable due to their lower density in the Cone Mosaic and their higher metabolic rate.
• Diseases of the inner retina (e.g. retinal ganglion cells), optic nerve and brain will result primarily in red-green defects.

The most notable exception is glaucoma, which affects the optic nerve, but is usually associated with blue-yellow defects.